Arrestin and Its Splice Variant Arr1–370A(p44)

Comparison of Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variant 1 in Different Stages of Endometriosis

Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants.

Arrestins constitute a family of small cytoplasmic proteins that mediate deactivation of G-protein-coupled receptors (GPCRs) and are known to be essential for cascade inactivation and receptor desensitization. Alternative splicing produces an array of arrestin gene products that have widely different specificities for their cognate receptors in vitro, but the differential functions of these spl...

MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides.

Alternative splicing has an important role in expanding protein diversity. An example of a gene with more than one transcript is the MDM2 oncogene. To date, more than 40 different splice variants have been isolated from both tumor and normal tissues. Here, we review what is known about the alteration of MDM2 mRNA expression, focusing on alternative splicing and potential functions of different ...

comparison of expression of growth hormone-releasing hormone and its receptor splice variant 1 in different stages of endometriosis

0

The predominant CD44 splice variant in prostate cancer binds fibronectin, and calcitonin stimulates its expression.

BACKGROUND Prostate cancer (PC) consistently overexpresses variant the (v) isoform of the cell adhesion protein CD44, and loses expression of the standard (s) isoform. MATERIALS AND METHODS We re-expressed CD44 full-length (exons 1-20) or standard (exons 1-5 + 16-20) or enforced stable RNAi against CD44v, and the examined functional effects on PC. The effect of stable knockout of calcitonin, ...